Karver Laboratory (CSH-017)

Summary 🟡 ~

Owner Unit: College of Science and Health
Sub-unit: Chemistry and Biochemistry
Content Type: center
Campus/Location: Lincoln Park (McGowan South 321D office; 325 lab)
Last Verified: May 30, 2026

Description & capabilities

Faculty medicinal and chemical-biology research group developing inhibitors and selective substrates for inflammatory caspases (caspase-1, -4, -5). Work combines synthetic organic chemistry, biochemical assays, fluorogenic peptide substrates, and structure–activity relationship (SAR) profiling.

Access status

Level: yellow (Negotiated Access)
Rationale: Karver Lab faculty profile documents McGowan South office and lab rooms; access through chemistry research affiliation.
Access URL: www.depaul.edu/faculty/caitlin-e-karver
Contact name: Caitlin E. Karver
Contact email: ckarver@depaul.edu
Verification date: 2026-05-30
Source URLs:
www.depaul.edu/faculty/caitlin-e-karver

Verification

Status: likely (~)
Confidence: 82/100
Rationale: Faculty-profile-anchored Karver Lab with published office/lab rooms and research focus.
Last verified: 2026-05-30
Evidence:
DePaul faculty profile McGowan South 321D/325 and caspase research program

Equipment

Find this resource from the Equipment catalog or site search (e.g. “3D printers”, “laser cutter”, “NMR”).

Category	Specific equipment
Spectrometers	Fluorogenic peptide-substrate assays; FRET-based caspase activity monitoring
Lab sample processing	Small-molecule synthesis and biochemical caspase inhibitor screening (McGowan South 325)

Source: Karver DePaul faculty profile (May 2026). Last verified: July 29, 2026.

Contacts (resource-level)

Website: Caitlin E. Karver — DePaul faculty profile
Email: Caitlin E. Karver

Last verified: May 30, 2026.

People & contacts

Named contacts from the people registry when publicly documented.

Caitlin E. Karver (Faculty lead) — ckarver@depaul.edu · Profile
Carey Southern (Affiliated faculty) — CSOUTHE2@depaul.edu · Profile
Kyle A. Grice (Affiliated faculty) — kgrice1@depaul.edu · Profile

Source URL

Official links and email are listed under Contacts above.

Documented Relationships

Medicinal chemistry research group; joint FRET-substrate projects with Southern Lab ([CSH-018](../CSH/CSH-018.md)) — documented in PUB-013, Design and Application of a Fluorogenic Assay for Monitoring Inflammatory Caspase Activity (DOI); uses shared McGowan instrumentation (CSH-001). Department chair also directs CSH-001/CSH-002/CSH-003 administration.

Linked Relationship IDs

Documented connections

Generated from publication↔resource and person↔publication registries. Superscript numbers open Sources below. Multiple sources on one claim are grouped as ^1,4. Grant links are listed on publication and grant pages.

Publications

Design and Application of a Fluorogenic Assay for Monitoring Inflammatory Caspase Activity (2018) — documented, produced by · DOI¹
Structural, computational, docking and biological studies of a triaminopyrimidine caspase-1 inhibitor (2024) — documented, documents collaboration · DOI²

Grice Laboratory — shared documented publication(s): PUB-014²
Southern Laboratory — shared documented publication(s): PUB-013¹

People on linked publications

Caitlin E. Karver (coauthor; PUB-013)¹
Carey Southern (coauthor; PUB-013)¹
Kyle A. Grice (coauthor; PUB-014)²

Sources

Karver faculty profile states fluorogenic FRET-based assay developed in Karver lab in collaboration with Carey Southern; McGowan South 325 lab on profile. Archived source retained by Resource Map maintainers. View current source
Karver faculty profile lists Kyle A. Grice and Caitlin E. Karver as coauthors, J. Mol. Struct. 2024; documents Grice↔Karver collaboration (no explicit facility acknowledgment). Archived source retained by Resource Map maintainers. View current source

Notes

Faculty-profile-anchored lab resource (May 2026).